Sigmar1^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Sigmar1^{tm1(KOMP)Wtsi}
• Name: sigma non-opioid intracellular receptor 1; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419417
• Gene: Sigmar1 Location: Chr4:41738493-41741359 bp, - strand Genetic Position: Chr4, 22.05 cM, cytoband A5-B2
• Alliance: Sigmar1^{tm1(KOMP)Wtsi} page
• IMPC: Sigmar1 gene page

Mutation origin

• Mutant Cell Lines: EPD0403_1_A08, EPD0403_1_C06, EPD0403_1_D08, EPD0403_1_E06, EPD0403_1_G05, EPD0403_1_G06, EPD0403_1_G07, EPD0403_1_H08
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 1723 starting at position 41739255 and ending at position 41739255 of Chromosome 4 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Sigmar1 Mutation: 22 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 3 reference(s)