Tg(Lck-tTA)1Doi
Transgene Detail

Summary

• Symbol: Tg(Lck-tTA)1Doi
• Name: transgene insertion 1, Christophe Benoist and Diane Mathis
• MGI ID: MGI:4418667
• Synonyms: LTH1, Tg(Lck-tTA)1Dim
• Transgene: Tg(Lck-tTA)1Doi Location: unknown
• Alliance: Tg(Lck-tTA)1Doi page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The Lck proximal promoter was used to drive expression of the TetR-VP16 transactivator (tTA). Several founder lines were produced with varying expression. This line expresses particularly in T cell lineages early in differentiation. (J:70595)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:70595 Labrecque N, et al., How much TCR does a T cell need?. Immunity. 2001 Jul;15(1):71-82
• All: 2 reference(s)