Tg(CD2-Tcra,Cd4-Tcrb)4CKang
Transgene Detail

Summary

• Symbol: Tg(CD2-Tcra,Cd4-Tcrb)4CKang
• Name: transgene insertion 4C, Sang-Mo Kang
• MGI ID: MGI:4415814
• Synonyms: 4C TCR
• Transgene: Tg(CD2-Tcra,Cd4-Tcrb)4CKang Location: unknown
• Alliance: Tg(CD2-Tcra,Cd4-Tcrb)4CKang page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Tcra,Cd4-Tcrb)4CKang expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: This transgene results from the coinjection of two constructs derived from a C57BL/6 hybridoma cell line responsive to BALB/c splenocytes. The Tcra construct under the control of the human CD2 promoter contains a cDNA including V alpha 8.5 sequence and the Tcrb construct under the control of the mouse Cd4 promoter (without the intronic silencer) contains a cDNA including V beta 13 sequence. (J:155848)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:155848 Brennan TV, et al., A new T-cell receptor transgenic model of the CD4+ direct pathway: level of priming determines acute versus chronic rejection. Transplantation. 2008 Jan 27;85(2):247-55
• All: 17 reference(s)