Gpr17^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Gpr17^{tm1(KOMP)Vlcg}
• Name: G protein-coupled receptor 17; targeted mutation 1, Velocigene
• MGI ID: MGI:4415438
• Synonyms: Gpr17^-
• Gene: Gpr17 Location: Chr18:32076050-32082689 bp, - strand Genetic Position: Chr18, 17.89 cM
• Alliance: Gpr17^{tm1(KOMP)Vlcg} page
• IMPC: Gpr17 gene page

Mutation origin

• Mutant Cell Lines: 12229B-B5, 12229B-C3, 12229E-A3, 12229E-D3, 12229E-F1, 12229E-F3, 12229E-G8
• Germline Transmission: Earliest citation of germline transmission: J:219560
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1 Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 1033bp between positions 32080026-32081058 of Chromosome 18 (Build GRCm39). The Gpr17 gene is nested inside Lims2 in the reverse strand such that its single coding exon is fully contained in the long intron 4 of Lims2. The lacZ and floxed neomycin selection cassette were inserted in frame after Gpr17's ATG without deleting any exons from Lims2. No Gpr17 mRNA was detected in the hypothalamus of homozygous mutant mice. (J:136110, J:219560)

Generation of the Gpr17^tm1(KOMP)Vlcg allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Gpr17 Mutation: 17 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 2 reference(s)