Tlr9^m6Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr9^m6Btlr
• Name: toll-like receptor 9; mutation 6, Bruce Beutler
• MGI ID: MGI:4415350
• Synonyms: CpG7, Liesgen
• Gene: Tlr9 Location: Chr9:106099797-106104075 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Tlr9^m6Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered among G3 progeny of an ENU mutagenized mouse in a screen for susceptibility to induction of colitis by low doses of dextran sodium sulfate (DSS). The molecular change, in the second, last exon of the gene, results in a G to T transversion at nucleotide position 1944 of the mRNA that replaces the neutral arginine at amino acid position 648 with the polar leucine (R643L). (J:155728)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr9 Mutation: 65 strains or lines available

References

• Original: J:155728 Brandl K, et al., Record for "CpG7", updated November 9, 2009. MGI Direct Data Submission 2009. 2009
• All: 1 reference(s)