Fcgr2b^tm1.1Jsv
Targeted Allele Detail

Summary

• Symbol: Fcgr2b^tm1.1Jsv
• Name: Fc receptor, IgG, low affinity IIb; targeted mutation 1.1, J Sjef Verbeek
• MGI ID: MGI:4399748
• Synonyms: FcgammaRIIB^fl, FcgammaRIIB^Flox, Fcgr2b^tm1.1Sjv
• Gene: Fcgr2b Location: Chr1:170786186-170804116 bp, - strand Genetic Position: Chr1, 78.02 cM
• Alliance: Fcgr2b^tm1.1Jsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154796
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the exon encoding the first extracellular domain (exon 4). A floxed neo cassette was inserted downstream of the exon encoding the transmembrane domain (exon 5). Cre-mediated recombination removed the neo cassette and left exons 4 and 5 floxed. (J:179175)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr2b Mutation: 49 strains or lines available

References

• Original: J:154796 Boross P, et al., Highly B lymphocyte-specific tamoxifen inducible transgene expression of CreER T2 by using the LC-1 locus BAC vector. Genesis. 2009 Nov;47(11):729-35
• All: 6 reference(s)