Tfap2e^tm1(cre)Will
Targeted Allele Detail

Summary

• Symbol: Tfap2e^tm1(cre)Will
• Name: transcription factor AP-2, epsilon; targeted mutation 1, Trevor Williams
• MGI ID: MGI:4398845
• Synonyms: Tcfap2e^ak
• Gene: Tfap2e Location: Chr4:126609799-126630033 bp, - strand Genetic Position: Chr4, 60.91 cM
• Alliance: Tfap2e^tm1(cre)Will page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154236
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutation: Insertion
• Tfap2e^tm1(cre)Will expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tfap2e (MGI:2679630)

• Mutation details: An IRES, cre, and frt flanked neo cassette were inserted into exon 4. Cre expression is detected in the olfactory bulb. Reduced endogenous transcript expression and cre transcript expression were confirmed by in situ hybridization. (J:154236)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tfap2e (mouse) Summary of all recombinase alleles driven by Tfap2e. Comparative matrix view of recombinase activities Alliance mouse Tfap2e gene page

Expression

In Mice Carrying this Mutation:

23 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2e Mutation: 10 strains or lines available

References

• Original: J:154236 Feng W, et al., Disorganized olfactory bulb lamination in mice deficient for transcription factor AP-2epsilon. Mol Cell Neurosci. 2009 Nov;42(3):161-71
• All: 4 reference(s)