Tg(Col10a1-Tg*L2263P)1Rpbh
Transgene Detail

Summary

• Symbol: Tg(Col10a1-Tg*L2263P)1Rpbh
• Name: transgene insertion 1, Raymond P Boot-Handford
• MGI ID: MGI:4397570
• Synonyms: ColXTg^cog
• Transgene: Tg(Col10a1-Tg*L2263P)1Rpbh Location: unknown
• Alliance: Tg(Col10a1-Tg*L2263P)1Rpbh page

Characterization of the Tg(Col10a1-Tg*L2263P)1Rpbh/Tg(Col10a1-Tg*L2263P)1Rpbh and Tg(Col10a1-Tg*L2263P)1Rpbh/0 mouse phenotype

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col10a1-Tg*L2263P)1Rpbh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tg (MGI:98733)	Transgene codes for a protein with a leucine to proline mutation.

• Mutation details: The collagen X promoter was ligated upstream of the cDNA sequence encoding the myc-tagged cog mutant form (a C to T transition yielding a leucine to proline change at residue 2263) of thyroglobulin (Tg). This line has 5 copies of the transgene at a single insertion site and expressed 17% and 33% the level of endogenous collagen X in the hemizygous and homozygous state, respectively. Expression of Tg protein in hypertrophic chondrocytes did not affect the normal secretion of collagen X. (J:154052)

Schematic of the Tg(Col10a1-Tg*L2263P)1Rpbh transgene

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:154052 Rajpar MH, et al., Targeted induction of endoplasmic reticulum stress induces cartilage pathology. PLoS Genet. 2009 Oct;5(10):e1000691
• All: 3 reference(s)