Tg(Aire-G6pc2/GFP)1Mand
Transgene Detail
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Symbol: |
Tg(Aire-G6pc2/GFP)1Mand |
Name: |
transgene insertion 1, Mark Anderson |
MGI ID: |
MGI:4367724 |
Synonyms: |
Adig |
Transgene: |
Tg(Aire-G6pc2/GFP)1Mand Location: unknown
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Alliance: |
Tg(Aire-G6pc2/GFP)1Mand page
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Transgene Type: |
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Transgenic (Reporter) |
Mutation: |
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Insertion
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Mutation details: The BAC clone RPCI23, 461E7 was modified by targeted replacement of the coding portion of exon 1, all of exon 2 and part of exon 3 of the Aire gene with a construct containing a beta globin donor and acceptor cassette, a G6pc2/GFP fusion sequence and SV40 polyadenylation signal. The resulting transgene does not express Aire. Two NOD and two C57BL/6 founders were produced. The two NOD founders were propagated.
(J:154359)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:154359 Gardner JM, et al., Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 8;321(5890):843-7 |
All: |
14 reference(s) |
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