Dp(7Gm7290-Th)1Lef
Targeted Allele Detail

Summary

• Symbol: Dp(7Gm7290-Th)1Lef
• Name: duplication, Chr 7, Louis Lefebvre 1
• MGI ID: MGI:4366954
• Synonyms: Dp1Lef, Dp^7AI, Dp(7Ascl2-Ins2)1Lef
• Gene: Dp(7Gm7290-Th)1Lef Location: Chr7:142232393-142523001 bp Genetic Position: Chr7, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153719
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Duplication, Insertion
• Dp(7Gm7290-Th)1Lef involves 3 genes/genome features (Gm7290, Gm6471, Th) View all
• Mutation details: Cre mediated targeted meiotic recombination (TAMERE) in mice carrying Ins2^tm1.1Nagy and Ascl2^tm2.1Nagy duplicated the genomic fragment between the loxP sites duplicating the Th gene. (J:153719)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dp(7Gm7290-Th)1Lef Mutation: 0 strains or lines available

References

• Original: J:153719 Lefebvre L, et al., The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region. Hum Mol Genet. 2009 Nov 15;18(22):4255-67
• All: 1 reference(s)