Tg(IVL-MYC*)3Gev
Transgene Detail

Summary

• Symbol: Tg(IVL-MYC*)3Gev
• Name: transgene insertion 3, Gerard Evan
• MGI ID: MGI:4366270
• Synonyms: Inv-Omomyc, Tg(Inv-omoMYC)3Gev
• Transgene: Tg(IVL-MYC*)3Gev Location: unknown
• Alliance: Tg(IVL-MYC*)3Gev page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(IVL-MYC*)3Gev expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Myc	(MGI:97250)

• Mutation details: The human involucrin promoter drives expression of a human MYC-derived basic helix-loop-helix zipper (bHLHZip) domain in which replacement of four charged amino acids (Glu57Thr, Glu64Ile, Arg70Glu, Arg71Asn) permits it to form homodimers, as well as heterodimers with endogenous MYC that interfere with the formation of MYC/MAX dimers and suppress binding to E-box elements. Immunohistochemical analysis of transgenic mouse skin using an antibody to the mutant bHLHZip demonstrated expression of the mutant protein in most suprabasal interfollicular keratinocytes and in the inner root sheath of hair follicles. (J:55801, J:101692, J:153799)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:101692 Soucek L, et al., Omomyc expression in skin prevents Myc-induced papillomatosis. Cell Death Differ. 2004 Sep;11(9):1038-45
• All: 3 reference(s)