Tcf3^tm4Cmu
Targeted Allele Detail

Summary

• Symbol: Tcf3^tm4Cmu
• Name: transcription factor 3; targeted mutation 4, Cornelis Murre
• MGI ID: MGI:4366004
• Synonyms: Tcfe2a^fl_E47
• Gene: Tcf3 Location: Chr10:80245348-80269481 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tcf3^tm4Cmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153423
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A floxed neo cassette was inserted upstream of the E47-specific exon and a loxP site was inserted downstream of this exon. A tetracysteine tag was inserted into exon 20. (J:153423)

Generation of Tcf3^tm3Cmu, Tcf3^tm3.1Cmu, Tcf3^tm4Cmu, and Tcf3^tm4.1Cmu alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf3 Mutation: 39 strains or lines available

References

• Original: J:153423 Beck K, et al., Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci. J Exp Med. 2009 Sep 28;206(10):2271-84
• All: 2 reference(s)