Grm2^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Grm2^{tm1(KOMP)Wtsi}
• Name: glutamate receptor, metabotropic 2; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4363695
• Gene: Grm2 Location: Chr9:106521733-106533308 bp, - strand Genetic Position: Chr9, 57.98 cM
• IMPC: Grm2 gene page

Mutation origin

• Mutant Cell Lines: EPD0322_1_A02, EPD0322_1_B01, EPD0322_1_B04, EPD0322_1_C02, EPD0322_1_C03, EPD0322_1_D01, EPD0322_1_D03, EPD0322_1_E01, EPD0322_1_E03, EPD0322_1_F01, EPD0322_1_F02, EPD0322_1_G03, EPD0322_1_H02, EPD0322_1_H03, EPD0322_1_H04
• Germline Transmission: Unknown
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Pgk_P
• Mutation details: The insertion of the L1L2_Pgk_P cassette created a deletion of size 4162 starting at position 106524302 and ending at position 106528464 of Chromosome 9 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm2 Mutation: 47 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 2 reference(s)