Lztfl1^{tm1e(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Lztfl1^{tm1e(KOMP)Wtsi}
• Name: leucine zipper transcription factor-like 1; targeted mutation 1e, Wellcome Trust Sanger Institute
• MGI ID: MGI:4363232
• Synonyms: Lztfl1 KO
• Gene: Lztfl1 Location: Chr9:123523469-123546690 bp, - strand Genetic Position: Chr9, 74.36 cM, cytoband F
• Alliance: Lztfl1^{tm1e(KOMP)Wtsi} page
• IMPC: Lztfl1 gene page

Obesity, ventriculomegaly, and retinal degneration in Lztfl1^{tm1e(KOMP)Wtsi}/Lztfl1^{tm1e(KOMP)Wtsi} mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Lines: EPD0264_2_B11, EPD0264_2_B12, EPD0264_2_D12, EPD0264_2_F11
• Germline Transmission: Earliest citation of germline transmission: J:226512
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Vector: L1L2_Pgk_P Mutation details: The L1L2_Pgk_P cassette was inserted at position 123540649 of Chromosome 9 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534, J:226512)

Generation of the Lztfl1^tm1e(KOMP)Wtsi allele

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Lztfl1 Mutation: 19 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 7 reference(s)