Vps16^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Vps16^{tm1(KOMP)Wtsi}
• Name: VSP16 CORVET/HOPS core subunit; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4362631
• Gene: Vps16 Location: Chr2:130266259-130286189 bp, + strand Genetic Position: Chr2, 63.22 cM, cytoband F3
• IMPC: Vps16 gene page

Mutation origin

• Mutant Cell Lines: EPD0323_3_A12, EPD0323_3_B09, EPD0323_3_B10, EPD0323_3_B12, EPD0323_3_C11, EPD0323_3_D11, EPD0323_3_E09, EPD0323_3_F12, EPD0323_3_G10
• Germline Transmission: Unknown
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 5183 starting at position 130279491 and ending at position 130284674 of Chromosome 2 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Vps16 Mutation: 35 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 2 reference(s)