Wnk4^tm2Suc
Targeted Allele Detail

Summary

• Symbol: Wnk4^tm2Suc
• Name: WNK lysine deficient protein kinase 4; targeted mutation 2, Shinichi Uchida
• MGI ID: MGI:4360552
• Gene: Wnk4 Location: Chr11:101151393-101168235 bp, + strand Genetic Position: Chr11, 64.51 cM
• Alliance: Wnk4^tm2Suc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152915
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A splice acceptor and floxed neo cassette was inserted upstream of exon 7 and an additional loxP site was inserted downstream of exon 7. (J:152915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnk4 Mutation: 58 strains or lines available

References

• Original: J:152915 Ohta A, et al., Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009 Oct 15;18(20):3978-86
• All: 1 reference(s)