Mom5^129P2/OlaHsd
QTL Variant Detail

Summary

• QTL variant: Mom5^129P2/OlaHsd
• Name: modifier of Min 5; 129P2/OlaHsd
• MGI ID: MGI:4359610
• Synonyms: Mom5^129P2
• QTL: Mom5 Location: Chr5:8847672-33475637 bp Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: 129P2/OlaHsd

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: The 129P2OlaHsd allele at this locus has a dominant effect to reduce intestinal adenoma number when inherited in conjunction with Apc^Min. 15 of 144 known genes located within this QTL region are polymorphic between 129P2/OlaHsd and C57BL/6J. (J:152194)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:152194

A Genetic linkage experiment was carried out to determine if there was a genetic modifier affected the number of intestinal tumors in Apc(min/+) mice. 129P2/OlaHsd (- /Erb) knockout mice were backcrossed to C57BL/6J - Apc(Min/+) mice for 10 generations (N10). At both N5 and N10 Erb(+/-) females were intercrossed with Apc(Min/+) males. Using STS markers linkage was analyzed at N5 whereby 10 of the intercross mice with the fewest intestinal adenomas were mated to 10 with the most intestinal adenomas. A more robust explanation of the linkage cross is reported in the methods section for this cross. The 1.5 LOD support interval ranges from D5Mit48 to D5Mit388 with a peak at D5Mit348. The QTL in this region is defined as Mom5 with Rint1 suggested as a strong candidate

References

• Original: J:152194 Oikarinen SI, et al., Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced intestinal tumorigenesis. Carcinogenesis. 2009 Sep;30(9):1591-6
• All: 1 reference(s)