Mnx1^tm1Slp
Targeted Allele Detail

Summary

• Symbol: Mnx1^tm1Slp
• Name: motor neuron and pancreas homeobox 1; targeted mutation 1, Samuel L Pfaff
• MGI ID: MGI:4359084
• Synonyms: Hb9 FL, Mnx1^tm1Spf
• Gene: Mnx1 Location: Chr5:29678821-29683468 bp, - strand Genetic Position: Chr5, 15.04 cM
• Alliance: Mnx1^tm1Slp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152526
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 of the targeted gene was flanked by loxP sites and a neomycin cassette flanked by FRT sites was introduced to intron 2. The targeting vector was electroporated into 129S1/Sv Oca2+ Tyr+ Kitl +-derived W9.5 embryonic stem (ES) cells. Chimeric animals were crossed to C57BL/6 and then to CB6F1 background FLP mice to remove the neomycin cassette before the strain was bred to homozygosity. (J:152526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mnx1 Mutation: 28 strains or lines available

References

• Original: J:152526 Pfaff SL, Generation of a floxed allele of Mnx1. MGI Direct Data Submission. 2009
• All: 1 reference(s)