Kalrntm1Ppen
Targeted Allele Detail
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Symbol: |
Kalrntm1Ppen |
Name: |
kalirin, RhoGEF kinase; targeted mutation 1, Peter Penzes |
MGI ID: |
MGI:4358076 |
Gene: |
Kalrn Location: Chr16:33789443-34393647 bp, - strand Genetic Position: Chr16, 24.27 cM
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Alliance: |
Kalrntm1Ppen page
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Brain region specific and age-dependent alterations in spine density in Kalrntm1Ppen/Kalrntm1Ppen mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:152011
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: The genomic sequence from exon 27 through exon 28 was replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on frontal cortex and hippocampus extracts.
(J:152011)
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Generation of the Kalrntm1Ppen allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kalrn Mutation: |
170 strains or lines available
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Original: |
J:152011 Cahill ME, et al., Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13058-63 |
All: |
7 reference(s) |
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