Lrrk2^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm1Arte
• Name: leucine-rich repeat kinase 2; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:4357791
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152261
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Intron 1 and exon 2 were targeted to create a knock-out. Western blot analysis confirmed the absence of protein expression in the brain. (J:152261, J:174288, J:206546)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 156 strains or lines available

References

• Original: J:152261 Gillardon F, Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in Parkinsonian neurodegeneration?. J Neurochem. 2009 Sep;110(5):1514-22
• All: 4 reference(s)