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Tg(Mef2c-ALPP)1Blk
Transgene Detail
Summary
Symbol: Tg(Mef2c-ALPP)1Blk
Name: transgene insertion 1, Brian L Black
MGI ID: MGI:4356434
Transgene: Tg(Mef2c-ALPP)1Blk  Location: unknown  
Alliance: Tg(Mef2c-ALPP)1Blk page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsA 3970-bp segment located from 16.3-20.3 kb downstream of Mef2c exon 1 and 51.1-55.1 kb upstream of the first coding exon (exon 5) was used to direct human placental alkaline phosphatase expression. This region of the mouse Mef2c gene contains enhancer and promoter sequences sufficient to direct expression in mouse embryos to the anterior heart field and its derivatives in the pharyngeal mesoderm, the right ventricle, and the outflow tract. (details provided by Dr. Brian L Black, personal Communication) (J:98489, J:152141)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:98489 Stennard FA, et al., Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development. 2005 May;132(10):2451-62
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/30/2025
MGI 6.24
The Jackson Laboratory