Atp2b2^Obv
Chemically induced Allele Detail

Summary

• Symbol: Atp2b2^Obv
• Name: ATPase, Ca++ transporting, plasma membrane 2; oblivion
• MGI ID: MGI:4355879
• Synonyms: DEA14, Obl
• Gene: Atp2b2 Location: Chr6:113720803-114019574 bp, - strand Genetic Position: Chr6, 52.85 cM
• Alliance: Atp2b2^Obv page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis created a C to T transition at position 2630 that results in an amino acid substitution of phenylalanine for serine at position 877 (S877F). This mutation occurs in transmembrane domain 6 of the PMCA2 pump, the resident calcium pump of the hair cell stereocilia. (J:151733)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atp2b2 Mutation: 66 strains or lines available

Notes

This mutant fails to compliment Atp2b2^dfw (J:151733).

References

• Original: J:151733 Spiden SL, et al., The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss. PLoS Genet. 2008 Oct;4(10):e1000238
• All: 2 reference(s)