Tg(Nes-cre/ERT2)7Vtlr
Transgene Detail

Summary

• Symbol: Tg(Nes-cre/ERT2)7Vtlr
• Name: transgene insertion 7, Verdon Taylor
• MGI ID: MGI:4355234
• Synonyms: nestin::CreER^T2
• Transgene: Tg(Nes-cre/ERT2)7Vtlr Location: unknown
• Alliance: Tg(Nes-cre/ERT2)7Vtlr page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Nes-cre/ERT2)7Vtlr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Nes (25491)

  Nes	(MGI:101784)

• Mutation details: A CreERT2 cDNA was with a rabbit globin poly-adenylation sequence. The 2.5-kb fragment of the CreERT2-polyA was inserted downstream of the transcription initiation site of a 5.7 kb fragment of the rat nestin promoter and 5.4 kb of the fused rat nestin introns I/III. The linearized fragment was injected into the pronuclei of fertilized oocytes. 11 transgenic founders were identified with eight of the 11 lines that were established showed similar inducible recombination in the nervous system. Line 7 was analyzed further. (J:151676)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Alliance rat Nes gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:151676 Giachino C, et al., Lineage analysis of quiescent regenerative stem cells in the adult brain by genetic labelling reveals spatially restricted neurogenic niches in the olfactory bulb. Eur J Neurosci. 2009 Jul;30(1):9-24
• All: 2 reference(s)