Klf2^tm1Khog
Targeted Allele Detail

Summary

• Symbol: Klf2^tm1Khog
• Name: Kruppel-like transcription factor 2 (lung); targeted mutation 1, Kristin A Hogquist
• MGI ID: MGI:4355064
• Synonyms: Klf2^GFP
• Gene: Klf2 Location: Chr8:73072906-73075498 bp, + strand Genetic Position: Chr8, 34.99 cM, cytoband C1
• Alliance: Klf2^tm1Khog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:151604
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An EGFP cassette was inserted in-frame at the translational start site in exon 1. A floxed neomycin cassette was also inserted downstream of exon 2. The fusion protein was detected in single-positive thymocytes. Because homozygote mice are viable and have normal lymphocyte numbers, the fusion protein was assumed to retain the function of the endogenous protein. (J:151604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf2 Mutation: 12 strains or lines available

References

• Original: J:151604 Weinreich MA, et al., KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 2009 Jul 17;31(1):122-30
• All: 12 reference(s)