Tpt1^tm1.1Atel
Targeted Allele Detail

Summary

• Symbol: Tpt1^tm1.1Atel
• Name: tumor protein, translationally-controlled 1; targeted mutation 1.1, Adam Telerman
• MGI ID: MGI:4353107
• Synonyms: tctp^delta3-5
• Gene: Tpt1 Location: Chr14:76082472-76085743 bp, + strand Genetic Position: Chr14, 40.29 cM
• Alliance: Tpt1^tm1.1Atel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150991
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neo cassette was inserted downstream of exon 5. Transient cre expression in ES cells removed exons 3 through 5 and the neo cassette. Reduced protein expression was confirmed by western blot analysis on organ samples from heterozygous mice. (J:150991)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tpt1 Mutation: 10 strains or lines available

References

• Original: J:150991 Susini L, et al., TCTP protects from apoptotic cell death by antagonizing bax function. Cell Death Differ. 2008 Aug;15(8):1211-20
• All: 1 reference(s)