Uggt1^{Gt(RST539)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Uggt1^{Gt(RST539)Byg}
• Name: UDP-glucose glycoprotein glucosyltransferase 1; gene trap RST539, BayGenomics
• MGI ID: MGI:4128266
• Synonyms: ugt1^-
• Gene: Uggt1 Location: Chr1:36179109-36283407 bp, - strand Genetic Position: Chr1, 15.15 cM
• Alliance: Uggt1^{Gt(RST539)Byg} page

Mutation origin

• Mutant Cell Line: RST539
• Germline Transmission: Earliest citation of germline transmission: J:255869
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT0TMpfs Vector Type: secretory trap
• Mutation details: The pGT0TMpfs gene trap, containing CD4 transmembrane domain/beta-galactosidase, neomycin phosphotransferase reporter fusion protein (beta-geo), inserted in intron 13. This truncates the coding region of the gene before exon 14 at codon 459 (versus 1551 wild-type). The catalytic domain is encoded by exons 34-41 so this yields a null allele. Immunoblots confirm that no peptide is produced from this allele. (J:255869)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RST539	CC249694 ; (MGI Seq Detail)	5' RACE	Chr1:36234930-36236683 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  25 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uggt1 Mutation: 101 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)