Angptl2^{Gt(IST12354B11)Tigm}
Gene trapped Allele Detail

Summary

• Symbol: Angptl2^{Gt(IST12354B11)Tigm}
• Name: angiopoietin-like 2; gene trap IST12354B11, Texas A&M Institute for Genomic Medicine
• MGI ID: MGI:4068107
• Synonyms: mAngptl2 (KD)
• Gene: Angptl2 Location: Chr2:33106081-33137729 bp, + strand Genetic Position: Chr2, 22.36 cM
• Alliance: Angptl2^{Gt(IST12354B11)Tigm} page

Mutation origin

• Mutant Cell Line: IST12354B11
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: Lex3.13 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector Vector: VICTR76 Vector Type: gene trap
• Mutation details: The beta-geo gene trap inserted into intron 1. Western blot analysis confirmed reduced protein expression in the heart, muscle and lung.
• Sequence Tags: Sequence tag details (2 tags)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  IST12354B11BBF1	EF911647 ; (MGI Seq Detail)	inverse PCR	Chr2:33110630-33111179 bp (-)
  IST12354B11HMF1	EF911701 ; (MGI Seq Detail)	inverse PCR	Chr2:33110853-33111179 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  3 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Angptl2 Mutation: 38 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 6 reference(s)