Fstl1^{Gt(P086B03)Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Fstl1^{Gt(P086B03)Wrst}
• Name: follistatin-like 1; gene trap P086B03, German Gene Trap Consortium
• MGI ID: MGI:3865165
• Synonyms: Fstl1^gt
• Gene: Fstl1 Location: Chr16:37597417-37656878 bp, + strand Genetic Position: Chr16, 26.48 cM
• Alliance: Fstl1^{Gt(P086B03)Wrst} page

Mutation origin

• Mutant Cell Line: P086B03
• Germline Transmission: Earliest citation of germline transmission: J:238836
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Hypomorph, Modified isoform(s))
• Mutation: Insertion of gene trap vector Vector: FlipROSACeoC-2
• Mutation details: The gene trap vector inserted into the second intron of the gene. At 2 months of age, there is an 50% reduction in gene expression in the kidney of the homozygous genetrap mouse compared with wild-type, suggesting that this mutation is a hypomorph. Expression of an alternative transcript of the gene appears to be unaffected by the gene trap insertion, suggesting a mechanism for the hypomorphic mutation. (J:238836)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  P086B03	CZ293576 ; (MGI Seq Detail)	5' RACE	Chr16:37597435-37597711 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  17 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fstl1 Mutation: 44 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 4 reference(s)