Lca5^{Gt(AG0283)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Lca5^{Gt(AG0283)Wtsi}
• Name: Leber congenital amaurosis 5 (human); gene trap AG0283, Wellcome Trust Sanger Institute
• MGI ID: MGI:3863997
• Synonyms: Lca5^gt
• Gene: Lca5 Location: Chr9:83272346-83323180 bp, - strand Genetic Position: Chr9, 45.42 cM
• Alliance: Lca5^{Gt(AG0283)Wtsi} page

Clinical and morphological assessment of Lca5^{Gt(AG0283)Wtsi}/Lca5^{Gt(AG0283)Wtsi} mouse retina

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: AG0283
• Germline Transmission: Earliest citation of germline transmission: J:174018
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: The gene trap vector inserted into intron 3. Northern blot and western blot analysis confirmed the absence of mRNA and protein expression in homozygous mice. (J:174018)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AG0283	CZ258843 ; (MGI Seq Detail)	5' RACE	multiple
  * GRCm39; (strand of gene trap mutagenesis)

Schematic of the Lca5^{Gt(AG0283)Wtsi} allele

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lca5 Mutation: 29 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 5 reference(s)