Slk^{Gt(BC0415)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Slk^{Gt(BC0415)Wtsi}
• Name: STE20-like kinase; gene trap BC0415, Wellcome Trust Sanger Institute
• MGI ID: MGI:3858304
• Synonyms: SLK^fs
• Gene: Slk Location: Chr19:47568458-47633685 bp, + strand Genetic Position: Chr19, 39.77 cM, cytoband D2
• Alliance: Slk^{Gt(BC0415)Wtsi} page

Mutation origin

• Mutant Cell Line: BC0415
• Germline Transmission: Earliest citation of germline transmission: J:211339
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT2lxr
• Mutation details: The gene trap vector inserted in intron 10. The insertion results in an in-frame splicing event and the expression of a fusion protein that lacks amino acids 795-1202 and is approximately 50 kDa larger than the endogenous protein. The fusion protein retains the catalytic kinase domain as well as the central coiled-coil region but lacks the ATH domain. (J:211339)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  BC0415	CW991101 ; (MGI Seq Detail)	5' RACE	Chr19:47609214-47610804 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  6 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	98 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slk Mutation: 56 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 2 reference(s)