Trim63^tm2.1Vlcg
Targeted Allele Detail

Summary

• Symbol: Trim63^tm2.1Vlcg
• Name: tripartite motif-containing 63; targeted mutation 2.1, Velocigene
• MGI ID: MGI:3851102
• Synonyms: deltaR-MuRF1^myc
• Gene: Trim63 Location: Chr4:134042431-134056940 bp, + strand Genetic Position: Chr4, 66.58 cM
• Alliance: Trim63^tm2.1Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150424
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 and 2 were replaced with a cDNA for those alleles lacking the coding region for the ring finger. A downstream floxed neo cassette was removed by transient cre expression. (J:150424)

Strategy for the generation of the Trim63^tm2.1Vlcg allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim63 Mutation: 18 strains or lines available

References

• Original: J:150424 Cohen S, et al., During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol. 2009 Jun 15;185(6):1083-95
• All: 2 reference(s)