Tg(tetO-Egfr*)2-9Jek
Transgene Detail

Summary

• Symbol: Tg(tetO-Egfr*)2-9Jek
• Name: transgene insertion 2-9, Jeffrey E Kudlow
• MGI ID: MGI:3850383
• Synonyms: TetRE-EGFR-tr, TRE-EGFR-tr
• Transgene: Tg(tetO-Egfr*)2-9Jek Location: unknown
• Alliance: Tg(tetO-Egfr*)2-9Jek page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Egfr*)2-9Jek expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Egfr (MGI:95294)

• Mutation details: The TetRE-EGFRtr-SV40 transgene was designed with the tetracycline operator (tetO; also called tetracycline-responsive element (TRE, TetRE) or tet-operator) and cytomegalovirus minimal promoter, a 2.3 kb C-terminal truncated mouse epidermal growth factor receptor cDNA sequence (EGFR-tr; encoding amino acid 1-690 followed by a TGA stop codon), and an SV40 intron/polyA sequence. This 4.5 kb transgene was microinjected into one-cell (C57BL/6 x SJL) mouse zygotes. Mice from founder lines 2-9 were bred with C57BL/6;SJL wildtype mice to establish the colony. (J:68692)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:68692 Roh M, et al., Stage-sensitive blockade of pituitary somatomammotrope development by targeted expression of a dominant negative epidermal growth factor receptor in transgenic mice. Mol Endocrinol. 2001 Apr;15(4):600-13
• All: 7 reference(s)