Erbin^tm1Line
Targeted Allele Detail

Summary

• Symbol: Erbin^tm1Line
• Name: Erbb2 interacting protein; targeted mutation 1, Lin Mei
• MGI ID: MGI:3849990
• Synonyms: erbin^-
• Gene: Erbin Location: Chr13:103955295-104057022 bp, - strand Genetic Position: Chr13, 56.16 cM, cytoband D1
• Alliance: Erbin^tm1Line page

Hypomyelination and abnormal axonal segregation in Remak bundles of Erbin^tm1Line/Erbin^tm1Line sciatic nerves

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149996
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 1 and 2 were replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on embryonic fibroblast extracts. (J:149996)

Generation of the Erbin^tm1Line allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbin Mutation: 62 strains or lines available

References

• Original: J:149996 Tao Y, et al., Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9477-82
• All: 7 reference(s)