Atoh1tm1(cre/ERT2)Mhos
Targeted Allele Detail
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Symbol: |
Atoh1tm1(cre/ERT2)Mhos |
Name: |
atonal bHLH transcription factor 1; targeted mutation 1, Mikio Hoshino |
MGI ID: |
MGI:3849084 |
Synonyms: |
Atoh1CreERn, Atoh1null |
Gene: |
Atoh1 Location: Chr6:64706109-64708229 bp, + strand Genetic Position: Chr6, 30.03 cM
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Alliance: |
Atoh1tm1(cre/ERT2)Mhos page
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Germline Transmission: |
Earliest citation of germline transmission:
J:149533
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inducible, Null/knockout, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Atoh1tm1(cre/ERT2)Mhos expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Atoh1 (MGI:104654) |
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Mutation details: The Atoh1 locus was targeted with a vector that replaced the open-reading frame (ORF) of the gene with the sequence encoding cre recombinase fused to a mutated estrogen ligand-binding domain (ERT2), resulting in a null allele.
(J:149533)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Atoh1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Atoh1 Mutation: |
36 strains or lines available
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Original: |
J:149533 Fujiyama T, et al., Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1. Development. 2009 Jun;136(12):2049-58 |
All: |
10 reference(s) |
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