Tg(HLA-A24/H2-D/B2M)3Dvs
Transgene Detail

Summary

• Symbol: Tg(HLA-A24/H2-D/B2M)3Dvs
• Name: transgene insertion 3, David V Serreze
• MGI ID: MGI:3848818
• Synonyms: A24/HHD
• Transgene: Tg(HLA-A24/H2-D/B2M)3Dvs Location: unknown
• Alliance: Tg(HLA-A24/H2-D/B2M)3Dvs page

Transgene origin

• Strain of Origin: NOD/ShiLtDvs

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(HLA-A24/H2-D/B2M)3Dvs expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  B2M (567)

  B2m	(MGI:88127)

  mouse

  H2-D (MGI:1933561)
• Mutation details: This transgene encodes human B2-microglubulin (B2M) covalently linked to the alpha1 and alpha2 peptide binding domains of the human HLA-A24 MHC class I gene, as well as the alpha3, cytoplasmic and transmembrane domains of the murine H2-Db class I variant. Human HLA-A2.1 and HLA-A24 have both been associated with T1D in humans. (J:149657)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:149657 Serreze DV, Generation of humanized HLA-A24 transgenic NOD mice. MGI Direct Data Submission. 2009
• All: 2 reference(s)