Kat6a^tm1.1Glac
Targeted Allele Detail

Summary

• Symbol: Kat6a^tm1.1Glac
• Name: K(lysine) acetyltransferase 6A; targeted mutation 1.1, Georges Lacaud
• MGI ID: MGI:3847653
• Synonyms: MOZ HAT^-
• Gene: Kat6a Location: Chr8:23349551-23433275 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Kat6a^tm1.1Glac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148955
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 11 was replaced with one in which nucleotide substitutions of GGC to GAG result in an amino acid substitution of glycine for glutamic acid at position 657 (G657E). This mutation abolishes HAT activity. A floxed neo inserted downstream of exon 11 was removed by transient, cre mediated recombination in ES cells. (J:148955)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat6a Mutation: 67 strains or lines available

References

• Original: J:148955 Perez-Campo FM, et al., The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors. Blood. 2009 May 14;113(20):4866-74
• All: 2 reference(s)