Nedd4l^tm1.1Blyg
Targeted Allele Detail

Summary

• Symbol: Nedd4l^tm1.1Blyg
• Name: neural precursor cell expressed, developmentally down-regulated gene 4-like; targeted mutation 1.1, Baoli Yang
• MGI ID: MGI:3846430
• Synonyms: Nedd4L^flox
• Gene: Nedd4l Location: Chr18:65020776-65350899 bp, + strand Genetic Position: Chr18, 37.57 cM, cytoband E1
• Alliance: Nedd4l^tm1.1Blyg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148641
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and frt flanked neo cassette were inserted into intron 5 and a single loxP site was inserted into intron 8 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 6 - 8 floxed. (J:148641)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nedd4l Mutation: 75 strains or lines available

References

• Original: J:148641 Shi PP, et al., Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol. 2008 Aug;295(2):F462-70
• All: 9 reference(s)