Pkd1^tm1.1Bol
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm1.1Bol
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Alessandra Boletta
• MGI ID: MGI:3846084
• Synonyms: Pkd1^flox
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm1.1Bol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148419
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into intron 43 and into the 3' untranslated region of the gene. Frt flanked neomycin cassette inserted into 3' end of the gene was removed by crossing with a Flp-expressing line. (J:148419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 153 strains or lines available

References

• Original: J:148419 Distefano G, et al., Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol Cell Biol. 2009 May;29(9):2359-71
• All: 2 reference(s)