Tln2^{Gt(S1-6D1)Sor}
Gene trapped Allele Detail

Summary

• Symbol: Tln2^{Gt(S1-6D1)Sor}
• Name: talin 2; gene trap S1-6D1, Philippe Soriano
• MGI ID: MGI:3844953
• Synonyms: Tln2^FHRC-S1-D6, Tln2^gt, Tln2^{Gt(FHCRC-GT-S1-6D1)Sor}
• Gene: Tln2 Location: Chr9:67124369-67466985 bp, - strand Genetic Position: Chr9, 36.39 cM
• Alliance: Tln2^{Gt(S1-6D1)Sor} page

Mutation origin

• Mutant Cell Line: S1-6D1
• Germline Transmission: Earliest citation of germline transmission: J:148426
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector: ROSAFARY
• Mutation details: A lentivirus based gene trap inserted into the intron 5' to the third non-coding exon upstream of the first coding exon (position 67396821 Ensembl build 37). Reduced protein expression in homozygotes was confirmed by western blot to be 80% in brain, 63% in heart, 93% in kidney, and 97% in spleen. (J:148426)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  FHCRC-GT-S1-6D1	CG425377 ; (MGI Seq Detail)	3' RACE	Chr9:67299830-67367270 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  74 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tln2 Mutation: 149 strains or lines available

References

• Original: J:148426 Debrand E, et al., Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms. FEBS J. 2009 Mar;276(6):1610-28
• All: 2 reference(s)