Tg(CDX2-cre*)189Erf
Transgene Detail

Summary

• Symbol: Tg(CDX2-cre*)189Erf
• Name: transgene insertion 189, Eric R Fearon
• MGI ID: MGI:3843611
• Synonyms: CDX2P9.5-G22Cre
• Transgene: Tg(CDX2-cre*)189Erf Location: unknown
• Alliance: Tg(CDX2-cre*)189Erf page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(CDX2-cre*)189Erf expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  CDX2 (1045)

  Cdx2	(MGI:88361)

• Mutation details: The CDX2P9.5-G22Cre transgene was designed with a 9.5 kb promoter fragment from the 5' flanking sequences of human caudal type homeo box 2 (CDX2) gene, a nuclear-localized Cre recombinase gene modified with a 22 guanine nucleotide repeat tract between its initiating methionine (ATG) codon and the remainder of the Cre-coding region, and a bovine growth hormone polyadenylation cassette. This transgene was injected into (C57BL/6J x SJL/J) hybrid cells. Transgenic founders (line 189) were found to have approximately 80 copies of the transgene and were bred to C57BL/6J mice. (J:148161)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CDX2 (human) Summary of all recombinase alleles driven by CDX2. Comparative matrix view of recombinase activities Alliance human CDX2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:148161 Akyol A, et al., Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene. Nat Methods. 2008 Mar;5(3):231-3
• All: 8 reference(s)