Tg(Tal1-ETV6/NTRK3)1Megr
Transgene Detail

Summary

• Symbol: Tg(Tal1-ETV6/NTRK3)1Megr
• Name: transgene insertion 1, Mel Greaves
• MGI ID: MGI:3843364
• Synonyms: TEL-TRKC L-type
• Transgene: Tg(Tal1-ETV6/NTRK3)1Megr Location: unknown
• Alliance: Tg(Tal1-ETV6/NTRK3)1Megr page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tal1-ETV6/NTRK3)1Megr expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ETV6 (2120)

  Etv6	(MGI:109336)

  human

  NTRK3 (4916)

  Ntrk3

  (MGI:97385)

• Mutation details: The +6E5 promoter fragment and 3' enhancer fragment of the mouse gene were used to drive hemangioblast/hematopoietic-specific expression of an ETV6/NTRK3 fusion cloned from human acute myeloid leukemia. Two lines were created. No line numbers were given. (J:96118)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tal1-ETV6/NTRK3)1Megr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:96118 Eguchi M, et al., Directing oncogenic fusion genes into stem cells via an SCL enhancer. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1133-8
• All: 1 reference(s)