Tg(KRT5-Akt1)1Jmpa
Transgene Detail

Summary

• Symbol: Tg(KRT5-Akt1)1Jmpa
• Name: transgene insertion 1, Jesus M Paramio
• MGI ID: MGI:3842828
• Synonyms: BK5.wtAkt
• Transgene: Tg(KRT5-Akt1)1Jmpa Location: unknown
• Alliance: Tg(KRT5-Akt1)1Jmpa page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-Akt1)1Jmpa expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Akt1 (MGI:87986)

• Tg(KRT5-Akt1)1Jmpa expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: The bovine promoter was used to drive epithelial-specific expression of a wild-type mouse Akt1. One line was created. (J:127302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127302 Segrelles C, et al., Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. Cancer Res. 2007 Nov 15;67(22):10879-88
• All: 2 reference(s)