Kmt5a^tm1.1Dare
Targeted Allele Detail

Summary

• Symbol: Kmt5a^tm1.1Dare
• Name: lysine methyltransferase 5A; targeted mutation 1.1, Danny Reinberg
• MGI ID: MGI:3842472
• Synonyms: PR-Set7^flox
• Gene: Kmt5a Location: Chr5:124577993-124600371 bp, + strand Genetic Position: Chr5, 63.59 cM
• Alliance: Kmt5a^tm1.1Dare page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147765
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed frt cassette with a 5' loxP was inserted upstream of exon 7, and an additional loxP site was inserted downstream of exon 7. Germ line, flp mediated recombination was used to remove the neo cassette leaving exon 7 floxed. (J:147765)

Expression

In Mice Carrying this Mutation:

20 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt5a Mutation: 47 strains or lines available

References

• Original: J:147765 Oda H, et al., Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol. 2009 Apr;29(8):2278-95
• All: 9 reference(s)