Mecp2^tm2Jae
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm2Jae
• Name: methyl CpG binding protein 2; targeted mutation 2, Rudolf Jaenisch
• MGI ID: MGI:3840524
• Synonyms: LSL-Mecp2^S80A
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm2Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147157
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutations: Insertion, Single point mutation Mutation details: Exons 3 and 4 were replaced by a floxed neo/STOP cassette, a modified exon 3 with a G to T point mutation that results in an amino acid substitution of serine with alanine at position 80, and a normal exon 4. (J:147157)

Generation of the Mecp2^tm2Jae allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 46 strains or lines available

References

• Original: J:147157 Tao J, et al., Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882-7
• All: 1 reference(s)