Cd63^tm1Psa
Targeted Allele Detail

Summary

• Symbol: Cd63^tm1Psa
• Name: CD63 antigen; targeted mutation 1, Paul Saftig
• MGI ID: MGI:3840228
• Synonyms: CD63^-
• Gene: Cd63 Location: Chr10:128736858-128748691 bp, + strand Genetic Position: Chr10, 77.19 cM
• Alliance: Cd63^tm1Psa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145741
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of neo expression cassette in the third codon of exon 2. Northern blotting and RT-PCR demonstrated a complete absence of Cd63 RNA in homozygous mutant mice. (J:145741)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd63 Mutation: 19 strains or lines available

References

• Original: J:145741 Schroder J, et al., Deficiency of the tetraspanin CD63 associated with kidney pathology but normal lysosomal function. Mol Cell Biol. 2009 Feb;29(4):1083-94
• All: 8 reference(s)