Hdlq92^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Hdlq92^C57BL/6J
• Name: HDL QTL 92; C57BL/6J
• MGI ID: MGI:3839758
• QTL: Hdlq92 Location: unknown Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased plasma HDL concentration in males on a CHOW diet compared to 129S1/SvImJ. (J:144089)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:144089

Linkage analysis was performed on 528 animals from a (C57BL/6J x 129S1/SvImJ)F2 intercross to map QTL associated with plasma HDL levels on either a CHOW or atherogenic diet. F2 animals were fed a CHOW diet until 8 weeks of age and then placed on an atherogenic diet until 16 weeks of age. An array of 508 SNPs was used for genome scan. Plasma HDL is significantly higher in 129S1/SvImJ parental strain compared to C57BL/7J on CHOW and high fat diets, with a stronger effect observed in males compared to females. Several previously identified HDL QTL were detected in this study as well as several novel loci, some of which showed interactive effects.

Hdlq21 (HDL QTL 21) on mouse Chromosome 3 mapped to 124.8 Mb (61.8 cM) near rs13477384 and is associated with increased plasma HDL on a CHOW diet (LOD=5.4). This QTL was identified in a previous study and has a male-specific effect. The Hdlq21 95% confidence interval spans 117 Mb (55 cM) to 129 Mb (162 cM). C57BL/6J-derived alleles at Hdlq21 confer increased plasma HDL in males on CHOW diet.

12.15.2014_djr Curator's Note: Because Hdlq21 was originally mapped in J:89309 in 2004 using a (SM/J x NZB/BlNJ)F2 intercross, which differs from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Hdlq92.

References

• Original: J:144089 Su Z, et al., Genetic basis of HDL variation in 129/SvImJ and C57BL/6J mice: importance of testing candidate genes in targeted mutant mice. J Lipid Res. 2009 Jan;50(1):116-25
• All: 1 reference(s)