Esr1^tm1Syeh
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1Syeh
• Name: estrogen receptor 1 (alpha); targeted mutation 1, Shuyuan Yeh
• MGI ID: MGI:3839670
• Synonyms: ERalpha^fl
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1Syeh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147191
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3, and a floxed self-excising neo cassette was inserted downstream of exon 3. The neo cassette sucessfully self-excises leaving exon 3 floxed. (J:147191)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 67 strains or lines available

References

• Original: J:147191 Chen M, et al., Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. Mol Cell Biochem. 2009 Jan;321(1-2):145-53
• All: 7 reference(s)