Gabbr2tm1Arca
Targeted Allele Detail
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Symbol: |
Gabbr2tm1Arca |
Name: |
gamma-aminobutyric acid type B receptor subunit 2; targeted mutation 1, Andrew R Calver |
MGI ID: |
MGI:3839235 |
Synonyms: |
deltaGB2-Ct |
Gene: |
Gabbr2 Location: Chr4:46662318-46991714 bp, - strand Genetic Position: Chr4, 25.18 cM
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Alliance: |
Gabbr2tm1Arca page
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Germline Transmission: |
Earliest citation of germline transmission:
J:146953
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 14 and 15 were replaced with a PGK neomycin selection cassette. The PGK neo cassette is spliced out during mRNA production and exon 13 is fused to exon 16 in the resulting mRNA. An additional six amino acids are added downstream of transmembrane domane 7. Expression of the mutant mRNA was confirmed by quantitative RT-PCR.
(J:146953)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gabbr2 Mutation: |
61 strains or lines available
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Original: |
J:146953 Thuault SJ, et al., The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Biochem Pharmacol. 2004 Oct 15;68(8):1655-66 |
All: |
1 reference(s) |
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