Ptprh^tm1Mato
Targeted Allele Detail

Summary

• Symbol: Ptprh^tm1Mato
• Name: protein tyrosine phosphatase receptor type H; targeted mutation 1, Takashi Matozaki
• MGI ID: MGI:3839027
• Synonyms: Sap1^flox
• Gene: Ptprh Location: Chr7:4551611-4607040 bp, - strand Genetic Position: Chr7, 2.63 cM
• Alliance: Ptprh^tm1Mato page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146871
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A neo cassette with a 5' loxP site was inserted upstream of exon 17, and an additional loxP site was inserted downstream of exon 18. Expression levels are less than in wild-type mice. This is a hypomorphic allele. (J:146871)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprh Mutation: 60 strains or lines available

References

• Original: J:146871 Sadakata H, et al., SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis. Genes Cells. 2009 Mar;14(3):295-308
• All: 1 reference(s)