Oxtr^tm2.1Knis
Targeted Allele Detail

Summary

• Symbol: Oxtr^tm2.1Knis
• Name: oxytocin receptor; targeted mutation 2.1, Katsuhiko Nishimori
• MGI ID: MGI:3838764
• Synonyms: Oxtr^{VenusdeltaNeo}
• Gene: Oxtr Location: Chr6:112450644-112466904 bp, - strand Genetic Position: Chr6, 52.27 cM, cytoband E3
• Alliance: Oxtr^tm2.1Knis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146587
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 3 was replaced with a modified version of a yellow fluorescent protein gene (Venus) and a floxed pgk-neo cassette was inserted in intron 3 via homologous recombination. The neo cassette was then removed by Cre mediated recombination. RT-PCR and autoradiogram analysis confirmed the absence of RNA expression and binding activity in brains from homozygous mice. (J:146587)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oxtr Mutation: 46 strains or lines available

References

• Original: J:146587 Yoshida M, et al., Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J Neurosci. 2009 Feb 18;29(7):2259-71
• All: 24 reference(s)